Felix K. Biwott
ABSTRACT
Enough evidence has revealed that competing endogenous RNAs (ceRNAs) activity of long non-coding RNAs (lncRNAs) plays an important role in pathological processes of human diseases including cardiovascular diseases. However, the role of lncRNA in atrial fibrillation (AF) and their implications still remain unclear to date. In this study, lncRNA-mRNA network related to AF was constructed based on the ceRNA theory. We first obtained lncRNAs with topological characteristics in the lncRNA-mRNA network. We then construct a co-expression network to identify the lncRNA-associated functions, and the mRNAs in the network were analyzed for the enriched pathways which showed that the pathways were related to AF. We then analyzed the dysregulation of lncRNA-mRNA in ceRNA network and obtained three lncRNAs as hub lncRNAs. The obtained results indicate that lncRNAs might exert the pathogenesis of AF. This might help in the understanding of molecular mechanisms of lncRNA in AF, providing novel lncRNAs as potential biomarkers and/or therapeutic targets.
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