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Molecular and Mechanical Pathways in Airway Smooth Muscle Relaxation

Published: 08 November 2021 Publication History

Abstract

Chemistry and physics play an important role in relaxing contracted airway smooth muscles (ASM). This work investigates whether combining the two will result in enhanced ASM relaxation. Isolated bovine trachea ASM strips were employed using acetylcholine before undergoing mechanically‐induced length oscillations, consisting of small oscillations superimposed on breathing‐like changes, followed by administration of a broncho‐relaxant agent. The agents used in this work are isoproterenol (ISO), Indomethacin (INDO), SB 203580, or PD 0980590, which are inhibitors of cyclooxygenase extracellular signal‐regulated kinase, 1/2 (ERK1/2), and p38 mitogen‐activated protein kinase, respectively. The ASM reactivity following these treatments is assessed. It is demonstrated that adding one of these agents, Indomethacin, ISO, or SB 203580 enhances the relaxation produced by the oscillation process while it does not work with PD0980590.

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                ICBIP '21: Proceedings of the 6th International Conference on Biomedical Signal and Image Processing
                August 2021
                91 pages
                ISBN:9781450390507
                DOI:10.1145/3484424
                Permission to make digital or hard copies of all or part of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. Copyrights for components of this work owned by others than ACM must be honored. Abstracting with credit is permitted. To copy otherwise, or republish, to post on servers or to redistribute to lists, requires prior specific permission and/or a fee. Request permissions from [email protected]

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                Published: 08 November 2021

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                Author Tags

                1. Airway smooth muscles
                2. Asthma
                3. Oscillation
                4. Respiratory disease
                5. Stiffness

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