skip to main content
10.1145/3494583.3494640acmotherconferencesArticle/Chapter ViewAbstractPublication PagesicibeConference Proceedingsconference-collections
research-article

Analysis on Lowering the Drug Development Cost while Improving the Manufactured Medicine's Quality

Published:09 January 2022Publication History

ABSTRACT

As an ever-growing industry, huge amount of efforts are spent in the R&D process of Pharmaceutical Engineering. However, it is still possible to lower the cost by applying the modern cloud based computational technology. The adaptation of which can provide extra storage space, platform for cooperation and a better way to choose clinical trial volunteers. Apart from the R&D cost, the quality of manufactured medicines are quite disappointing, much lower than the figure for other industries. It does not only arouse waste issue, but also increases the number of substandard medicines, which could circulate on the market and trigger potential public health problems. As two possible ways to promote the quality of manufactured medicine, the continuous production method and 3D printing method are introduced in this paper to provide some references for the future development of the drug development.

References

  1. Greenm™ Green M, How data is accelerating drug discovery and development? June 14, 2021.Google ScholarGoogle Scholar
  2. Hegde, R. S, Firstpost, Why branded drugs cost way more than their generic COUNTERPARTS-INDIA News. April 29, 2017.Google ScholarGoogle Scholar
  3. Neuman, S, Pharmaceutical industry WASTES $50 billion a year due to Inefficient manufacturing: The Source: Washington University in St. Louis. The Source. January 13, 2016.Google ScholarGoogle Scholar
  4. World Health Organization. (n.d.), Substandard and falsified medical products. World Health Organization. https://www.who.int/news-room/fact-sheets/detail/substandard-and-falsified-medical-products.Google ScholarGoogle Scholar
  5. McCarthy, A. fdata-02-00023.pdf. Drug Discovery in the Clouds. 2002.Google ScholarGoogle Scholar
  6. Financialnewsmedia.com, Why Pharmaceutical R&D Global Spending Could Exceed $200 Billion by 2024. December 11, 2019.Google ScholarGoogle Scholar
  7. Singh, A, Pharmaceutical R&D global spending trends in 2019 - PRESCOUTER - Custom intelligence from a global network of experts. PreScouter. January 21, 2020Google ScholarGoogle Scholar
  8. Gunner Laine Hardy, Simulation Plus: One-Of-A-Kind Bioinformatics Co.With A 20% 3-Year CAGR. August 3, 2020.Google ScholarGoogle Scholar
  9. Sertkaya, Aylin, Hui-Hsing Wong, Amber Jessup, and Trinidad Beleche. Key cost drivers of pharmaceutical clinical trials in the United States, Web of Science, vol.13 (2), no.10,  Feb 8, 2016, pp121-122.Google ScholarGoogle ScholarCross RefCross Ref
  10. Patricio Ledesma, How Much Does a Clinical Trial Cost? January 2, 2020.Google ScholarGoogle Scholar
  11. McCarthy, A. fdata-02-00023.pdf. Drug Discovery in the Clouds. 2012. https://doi.org/DOI 10.1016/j.chembiol.2012.01.009Google ScholarGoogle Scholar
  12. Challener, C. A. (n.d.). Accelerating drug development with cloud-based computing. CIOReview. https://pharma-life-sciences.cioreview.com/cxoinsight/accelerating-drug-development-with-cloudbased-computing-nid-12895-cid-36.htmlGoogle ScholarGoogle Scholar
  13. Lucidchart, Cloud computing 101: Scalability, reliability, and availability. November 9, 2020.Google ScholarGoogle Scholar
  14. Massey, S. Making the Switch: Continuous Manufacturing vs. batch processing of pharmaceuticals. Xtalks, May 8, 2020.Google ScholarGoogle Scholar
  15. Number of Drug Recalls surges at FDA, led by Mid-Level Concerns. Regulatory Affairs Professionals Society (RAPS). (n.d.), 2014.Google ScholarGoogle Scholar
  16. CFR - code of federal Regulations Title 21. accessdata.fda.gov. (n.d.). https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRSearch.cfm?CFRPart=7&showFR=1Google ScholarGoogle Scholar
  17. General Kinematics. Batch vs. Continuous pharmaceutical manufacturing. General Kinematics, October 11, 2017.Google ScholarGoogle Scholar
  18. Clarivate, The future of continuous manufacturing in pharma. May 30, 2020.Google ScholarGoogle Scholar
  19. The generic drug supply chain. Association for Accessible Medicines. (n.d.). https://accessiblemeds.org/resources/blog/generic-drug-supply-chain.Google ScholarGoogle Scholar
  20. Khaled, Shaban A., 3D Printing of Five-in-One Dose Combination Polypill with Defined Immediate and Sustained Release Profiles. [J] Journal of Controlled Release, vol. 217, 2015, pp. 308–314.Google ScholarGoogle ScholarCross RefCross Ref
  21. Jassim, Z. E. (n.d.). View of application of 3d printing In Innovated drug DELIVERY: A Review: International Journal of Applied Pharmaceutics. View of APPLICATION OF 3D PRINTING IN INNOVATED DRUG DELIVERY: A REVIEW | International Journal of Applied Pharmaceutics. https://innovareacademics.in/journals/index.php/ijap/article/view/41741/25097.Google ScholarGoogle Scholar
  22. Additive manufacturing: Thermo fisher scientific. CN. (n.d.). https://www.thermofisher.cn/cn/zh/home/industrial/spectroscopy-elemental-isotope-analysis/materials-science-research/additive-manufacturing.html.Google ScholarGoogle Scholar
  23. Wong, S, 3D printing: risks vs. benefits for the pharma industry, PharmaTimes. May 29, 2018.Google ScholarGoogle Scholar
  24. Chen, A. (n.d.). Benefits vs drawbacks of 3D printing in the Pharmaceutical industry. November 28, 2019.Google ScholarGoogle Scholar

Recommendations

Comments

Login options

Check if you have access through your login credentials or your institution to get full access on this article.

Sign in
  • Published in

    cover image ACM Other conferences
    ICIBE '21: Proceedings of the 7th International Conference on Industrial and Business Engineering
    September 2021
    411 pages
    ISBN:9781450390644
    DOI:10.1145/3494583

    Copyright © 2021 ACM

    Permission to make digital or hard copies of all or part of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. Copyrights for components of this work owned by others than ACM must be honored. Abstracting with credit is permitted. To copy otherwise, or republish, to post on servers or to redistribute to lists, requires prior specific permission and/or a fee. Request permissions from [email protected]

    Publisher

    Association for Computing Machinery

    New York, NY, United States

    Publication History

    • Published: 9 January 2022

    Permissions

    Request permissions about this article.

    Request Permissions

    Check for updates

    Qualifiers

    • research-article
    • Research
    • Refereed limited
  • Article Metrics

    • Downloads (Last 12 months)6
    • Downloads (Last 6 weeks)2

    Other Metrics

PDF Format

View or Download as a PDF file.

PDF

eReader

View online with eReader.

eReader

HTML Format

View this article in HTML Format .

View HTML Format