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Dependence of neurons mortality on synaptogenesis in conditional mutant mice models

Published: 22 December 2021 Publication History

Abstract

Neurons originate from stem cells. Adult neurogenesis continuously occurs in specific areas of the rostral lateral ventricles and the hippocampus. Microglia is an essential components of the normal hippocampus as it can remove and kill damaged cells and infections through phagocytosis to help hippocampal neurons to stay homeostasis. Internal and external stimuli can trigger different responses from microglia. Inhibition of neuron firing would disrupt neuron function like synapse formation and synaptic function, which would increase microglia activity, and cause more neurons to be removed. In this work, hM4Di conditional mutant mice models were used to study the dependence of neuron mortality on synaptogenesis. CNO was injected to the mice to activate the hM4Di G protein-coupled receptor to trigger inhibition of neuron firing. This work made a contribution to discover the relationship of neuron mortality and synaptogenesis, which may provide a new strategy to find a therapy to cure Alzheimer's disease and depression.

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  1. Dependence of neurons mortality on synaptogenesis in conditional mutant mice models

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    ISAIMS '21: Proceedings of the 2nd International Symposium on Artificial Intelligence for Medicine Sciences
    October 2021
    593 pages
    ISBN:9781450395588
    DOI:10.1145/3500931
    Permission to make digital or hard copies of all or part of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. Copyrights for components of this work owned by others than ACM must be honored. Abstracting with credit is permitted. To copy otherwise, or republish, to post on servers or to redistribute to lists, requires prior specific permission and/or a fee. Request permissions from [email protected]

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    Published: 22 December 2021

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    Author Tags

    1. DREAAD expression
    2. mutant mice model
    3. neurons mortality
    4. synaptogenesis

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