skip to main content
10.1145/3523286.3524539acmotherconferencesArticle/Chapter ViewAbstractPublication PagesbicConference Proceedingsconference-collections
research-article

New Hash-based Sequence Alignment Algorithm

Published: 31 May 2022 Publication History

Abstract

With the gradual deepening of human understanding of the disease and the continuous improvement of diagnosis and treatment, precision medicine, a new medical concept medical model, has been proposed. High-throughput and high-accuracy gene sequence reading and high-accuracy and rapid gene sequence alignment provide the basis for diagnosing and treating precision medicine. This paper presents a new method based on matrix and linked-list to store sequence information. The hash values of the two hash functions are used as the coordinate values of the sequence in the matrix, and they can be used to find the target sequence. The algorithm is compared with five classical comparison algorithms.

References

[1]
Naibin Liu. Research on modularization of gene sequencing industrial organization in China [J]. Journal of Liaoning University of Technology (SOCIAL SCIENCE EDITION), 2020 (4).
[2]
Kadri S, Long B C, Mujacic I, Clinical Validation of a Next-Generation Sequencing Genomic Oncology Panel via Cross-Platform Benchmarking against Established Amplicon Sequencing Assays[J]. Journal of Molecular Diagnostics, 2017, 19(1):43-56.
[3]
Chang Kai, Liu Chenxia, Xu Hongxuan, Overview of the development and application of gene sequencing in precision medicine [J]. Southwest Military Medicine, 23 (2): 3.
[4]
MARDIS E R. The impact of next-generation sequencing technology on genetics[J]. Trends in Genetics, 2008,24(3):133-141.
[5]
Kai Xu. Optimizing High-throughput Biological Gene Sequencing Data Processing Algorithms based on Hash[D]. Jinan: Shandong University,2020:21-22.
[6]
Zheng J, Zhang W Q, Luo J, Variant Map System to Simulate Complex Properties of DNA Interactions Using Binary Sequences[J]. Advances in Pure Mathematics, 2013, 3(7A):5-24.
[7]
Karp, Richard, M, Efficient randomized pattern-matching algorithms[J]. IBM Journal of Research and Development, 1987, 31(2):249-260.
[8]
Shulin Wang, Wang Ji, Chen Huang, Research on k-long DNA subsequence counting algorithm [J]. Computer Engineering, 2007 (09): 40-42.
[9]
Jeffrey Zheng. Variant Construction from Theoretical Foundation to Applications[M]. Berlin: Springer Press, 2019:193-202.
[10]
Chu Hua. Software designer course (4th. ed.) [M]. Beijing: Tsinghua University Press, 2014: 435-436.
[11]
Knuth, D. E., Morris, J. H., & Pratt, V. R. . (1977). Fast pattern matching in strings. Siam Journal on Computing, 6(2), 323-350.
[12]
Boyer R.S., Moore J.S. A fast string searching algorithm. Communications of the ACM.20:762-772.
[13]
Sunday D.M.1990, A very fast substring search algorithm, Communications of the ACM. 33(8):132-142.

Recommendations

Comments

Information & Contributors

Information

Published In

cover image ACM Other conferences
BIC '22: Proceedings of the 2022 2nd International Conference on Bioinformatics and Intelligent Computing
January 2022
551 pages
ISBN:9781450395755
DOI:10.1145/3523286
Permission to make digital or hard copies of all or part of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. Copyrights for components of this work owned by others than ACM must be honored. Abstracting with credit is permitted. To copy otherwise, or republish, to post on servers or to redistribute to lists, requires prior specific permission and/or a fee. Request permissions from [email protected]

Publisher

Association for Computing Machinery

New York, NY, United States

Publication History

Published: 31 May 2022

Permissions

Request permissions for this article.

Check for updates

Author Tags

  1. Hash
  2. Rabin Karp algorithm
  3. Sequence Alignment
  4. Shulin Wang method
  5. k-mer
  6. linked-list

Qualifiers

  • Research-article
  • Research
  • Refereed limited

Conference

BIC 2022

Contributors

Other Metrics

Bibliometrics & Citations

Bibliometrics

Article Metrics

  • 0
    Total Citations
  • 34
    Total Downloads
  • Downloads (Last 12 months)8
  • Downloads (Last 6 weeks)1
Reflects downloads up to 08 Mar 2025

Other Metrics

Citations

View Options

Login options

View options

PDF

View or Download as a PDF file.

PDF

eReader

View online with eReader.

eReader

HTML Format

View this article in HTML Format.

HTML Format

Figures

Tables

Media

Share

Share

Share this Publication link

Share on social media