Pan-cancer analysis of CDCA2 and its function in papillary renal cell carcinoma
Authors: 
Fang Li, Qiuyu Jiang, Jinyuan Zhang, Xintao Jing, Xiaofei Wang, Chen HuangAuthors Info & Claims
Fang Li, Qiuyu Jiang, Jinyuan Zhang, Xintao Jing, Xiaofei Wang, Chen HuangAuthors Info & ClaimsPages 94 - 101
Abstract
Papillary renal cell carcinoma (PRCC) is the second most common type of Renal cell carcinoma (RCC) with insidious early symptoms and low clinical detection rate. Studies have reported that higher CDCA2 expression levels are associated with several cancers, but no studies have comprehensively analyzed cell division cycle-associated protein 2 (CDCA2) expression in pan-cancer and the role of CDCA2 in PRCC. In the present study, we analyzed the expression and clinical prognostic value of CDCA2 in pan-cancer including PRCC and find that CDCA2 was mainly involved in the progression of Adrenocortical carcinoma (ACC), Kidney renal papillary cell carcinoma (KIRP) and Liver hepatocellular carcinoma (LIHC). PRCC data from the Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) databases showed that CDCA2 expression was elevated in PRCC and was significantly associated with clinical stage and patient survival. Furthermore, data from The Tumor Immunity Estimation Resource (TIMER) database indicated that the expression of CDCA2 was closely related to the degree of immune infiltration of PRCC. In addition, Gene Set Enrichment Analysis (GSEA) analysis showed that CDCA2 is mainly involved in DNA replication, homologous recombination, linoleic acid metabolism and primary immunodeficiency. In conclusion, the present study suggested that CDCA2 may be a new marker molecule for PRCC and may serve as a targeted therapeutic molecule for PRCC.
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- Pan-cancer analysis of CDCA2 and its function in papillary renal cell carcinoma
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Published In
May 2022
190 pages
ISBN:9781450396387
DOI:10.1145/3543377
Copyright © 2022 ACM.
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Published: 08 August 2022
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- The Scientific Research and Sharing Platform Construction Project of Shaanxi Province
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ICBBT 2022
ICBBT 2022: 2022 14th International Conference on Bioinformatics and Biomedical Technology
May 27 - 29, 2022
Xi'an, China
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