Xueling Wang
ABSTRACT
Alzheimer's disease (AD) is a neurodegenerative disease in which Aβ accumulation occurs early in the disease. It is characterized by memory loss and progressive neurocognitive dysfunction. Theta rhythm, slow gamma rhythm and fast gamma rhythm of the hippocampus exhibit important contributions to the encoding and retrieval of memory. Previous studies have shown that gamma rhythms were impaired in AD model animals under free exploration behaviors. However, little is known about how the neural dynamics is changed under spatial memory state as AD rats performed a mnemonic task. We recorded the local field potential of hippocampal CA1 in rats during the free exploration task and a delayed match-to-sample spatial memory task, and the effects of Aβ on neural rhythm in two behavioral phase were analyzed. Our study found that injection of Ab reduced the power of slow gamma and fast gamma during the free exploration phase, while the decrement of fast gamma power was further exacerbated during the memory phase. In addition, Aβ also reduces the theta-fast gamma coupling strength in the free exploration phase. These findings provide new evidence for impairment of high frequency neural rhythm during memory phase of AD model rats, which could be a potential target of neural modulation for AD.
- Atul Adya, Paramvir Bahl, Jitendra Padhye, Alec Wolman, and Lidong Zhou. 2004. A multi-radio unification protocol for IEEE 802.11 wirelessGoogle Scholar
- Selkoe D. J. and Hardy J. 2016. The amyloid hypothesis of Alzheimer's disease at 25 years. EMBO Mol Med. 8, 6 (Jun 2016). 595-608. https://doi.org/10.15252/emmm.201606210Google ScholarCross Ref
- Colgin L. L. 2016. Rhythms of the hippocampal network. Nat Rev Neurosci. 17, 4 (Apr 2016). 239-49. https://doi.org/10.1038/nrn.2016.21Google ScholarCross Ref
- Colgin L. L. 2015. Theta-gamma coupling in the entorhinal-hippocampal system. Current opinion in neurobiology. 31, (Apr 2015). 45-50. https://doi.org/10.1016/j.conb.2014.08.001Google Scholar
- Mably A. J., Gereke B. J., Jones D. T. and Colgin L. L. 2017. Impairments in spatial representations and rhythmic coordination of place cells in the 3xTg mouse model of Alzheimer's disease. Hippocampus. 27, 4 (Apr 2017). 378-392. https://doi.org/10.1002/hipo.22697Google ScholarCross Ref
- Jun H., Bramian A., Soma S., Saito T., Saido T. C. and Igarashi K. M. 2020. Disrupted Place Cell Remapping and Impaired Grid Cells in a Knockin Model of Alzheimer's Disease. Neuron. 107, 6 (Sep 23 2020). 1095-1112.e6. https://doi.org/10.1016/j.neuron.2020.06.023Google ScholarCross Ref
- Iaccarino H. F., Singer A. C., Martorell A. J., Rudenko A., Gao F., Gillingham T. Z., Mathys H., Seo J., Kritskiy O., Abdurrob F., Adaikkan C., Canter R. G., Rueda R., Brown E. N., Boyden E. S. and Tsai L. H. 2016. Gamma frequency entrainment attenuates amyloid load and modifies microglia. Nature. 540, 7632 (Dec 7 2016). 230-235. https://doi.org/10.1038/nature20587Google ScholarCross Ref
- Bazzigaluppi P., Beckett T. L., Koletar M. M., Lai A. Y., Joo I. L., Brown M. E., Carlen P. L., McLaurin J. and Stefanovic B. 2018. Early-stage attenuation of phase-amplitude coupling in the hippocampus and medial prefrontal cortex in a transgenic rat model of Alzheimer's disease. Journal of neurochemistry. 144, 5 (Mar 2018). 669-679. https://doi.org/10.1111/jnc.14136Google ScholarCross Ref
- Zheng C., Bieri K. W., Hwaun E. and Colgin L. L. 2016. Fast Gamma Rhythms in the Hippocampus Promote Encoding of Novel Object-Place Pairings. eNeuro. 3, 2 (Mar-Apr 2016). https://doi.org/10.1523/eneuro.0001-16.2016Google Scholar
- Canolty R. T., Edwards E., Dalal S. S., Soltani M., Nagarajan S. S., Kirsch H. E., Berger M. S., Barbaro N. M. and Knight R. T. 2006. High gamma power is phase-locked to theta oscillations in human neocortex. Science (New York, NY). 313, 5793 (Sep 15 2006). 1626-8. https://doi.org/10.1126/science.1128115Google Scholar
- Zheng C., Bieri K. W., Trettel S. G. and Colgin L. L. 2015. The relationship between gamma frequency and running speed differs for slow and fast gamma rhythms in freely behaving rats. Hippocampus. 25, 8 (Aug 2015). 924-38. https://doi.org/10.1002/hipo.22415Google ScholarCross Ref
Index Terms
- Impairment of Neural Rhythms in the Hippocampus in Different Behavioral Phases Induced by Amyloid-β Accumulation
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