Xuan Luo
ABSTRACT
Spatial decision-making requires memory retrieval of spatial information related to choices, which relies on the hippocampus as its important role in the information processing during spatial decision-making. Theta rhythms temporally coordinate sequences of hippocampal place cell ensembles during spatial exploration, representing ongoing spatiotemporal experiences. Previous studies showed that place cell sequences that occurred near the choice point alternately represented potential future trajectories. However, little is known about whether the sequential representation at the early phase of decision exists prominent prediction to the subsequent choice. In this study, we applied offline and online decoding algorithms to investigate the predictive firing modes of place cell ensembles at specific decision phases. We found that the place cell sequences detected at the early phase by preferentially representing the alternative choice to predict the subsequent actual choice. These results provide evidences for early prediction of decision-making which could be applied to online detection and closed-loop modulation of animal decision.
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Index Terms
- Predictive Coding of Hippocampal Place Cell Ensembles during Early Phase of Spatial Decision-making
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