Sushil Kumar Jain
ABSTRACT
This paper presents the numerical simulation to detect the breast cancer biomarker (C-erbB-2) in saliva/serum using an organic thin-film transistor (OTFT). The numerical model for the C-erbB-2 interface charge equivalent is used. The biosensor is intended to detect C-erbB-2 with high sensitivity in blood serum samples. The numerical simulation is carried out with the help of the SILVACO ATLAS software, which allows for the modeling of the OTFT operation for detecting the C-erbB-2 biomarker. The sensitivity of the biosensor is investigated by varying the concentration of the cancer biomarker C-erbB-2 and observing the corresponding changes in the device's electrical characteristics. The proposed OTFT-based biosensor is a promising platform for the early detection of breast cancer. It can be integrated into wearable or implantable medical devices to monitor C-erbB-2 levels in the body continuously. The biosensor can detect varying levels of C-erbB-2 biomarkers in serum as well as in saliva, and the value of the maximum drain current sensitivity is obtained as 5.557 x 102.
- Deepak Bharti and Shree Prakash Tiwari. 2016. Crystallinity and performance improvement in solution processed organic field-effect transistors due to structural dissimilarity of the additive solvent. Synthetic Metals 215 (2016), 1--6.Google Scholar
Cross Ref
- Anju Gedam, Bibhudendra Acharya, and Guru Prasad Mishra. 2021. Design and Performance Assessment of Dielectrically Modulated Nanotube TFET Biosensor. IEEE Sens. J. 21, 15 (Aug. 2021), 16761--16769.Google ScholarCross Ref
- Ophira Ginsburg, Cheng-Har Yip, Ari Brooks, Anna Cabanes, Maira Caleffi, Jorge Antonio Dunstan Yataco, Bishal Gyawali, Valerie McCormack, Myrna McLaughlin de Anderson, Ravi Mehrotra, Alejandro Mohar, Raul Murillo, Lydia E Pace, Electra D Paskett, Anya Romanoff, Anne F Rositch, John R Scheel, Miriam Schneidman, Karla Unger-Saldaña, Verna Vanderpuye, Tsu-Yin Wu, Safina Yuma, Allison Dvaladze, Catherine Duggan, and Benjamin O Anderson. 2020. Breast cancer early detection: A phased approach to implementation. Cancer 126 Suppl 10, S10 (2020), 2379--2393.Google Scholar
- Anubha Goel, Sonam Rewari, Seema Verma, S S Deswal, and R S Gupta. 2021. Dielectric Modulated Junctionless Biotube FET (DM-JL-BT-FET) Bio-Sensor. IEEE Sens. J. 21, 15 (2021), 16731--16743.Google ScholarCross Ref
- Dipti Gupta, Namho Jeon, and Seunghyup Yoo. 2008. Modeling the electrical characteristics of TIPS-pentacene thin-film transistors: Effect of contact barrier, field-dependent mobility, and traps. Org. Electron. 9, 6 (2008), 1026--1031.Google ScholarCross Ref
- S A Hafiz, I M Ehteshamuddin, and S A Loan. 2019-02. Dielectrically Modulated Source-Engineered Charge-Plasma-Based SchottkyFET as a Label-Free Biosensor. IEEE Trans. Electron Devices 66, 4 (2019-02), 1905--1910,.Google ScholarCross Ref
- Prateek Jain and Amit Mahesh Joshi. 2017. Low leakage and high CMRR CMOS differential amplifier for biomedical application. Analog Integrated Circuits and Signal Processing 93, 1 (2017), 71--85.Google ScholarDigital Library
- Prateek Jain, Amit M Joshi, Navneet Agrawal, and Saraju Mohanty. 2020. iGLU 2.0: A new non-invasive, accurate serum glucometer for smart healthcare. arXiv preprint arXiv:2001.09182 (2020).Google Scholar
- SK Jain, AM Joshi, and D Bharti. 2020. Performance Investigation of Organic Thin Film Transistor on Varying Thickness of Semiconductor Material: An Experimentally Verified Simulation Study. Semiconductors 54, 11 (2020), 1483--1489.Google ScholarCross Ref
- Sushil Kumar Jain, Amit Mahesh Joshi, and Linga Reddy Cenkeramaddi. 2023. Dielectric Modulated Bilayer Electrode Top Contact OTFT for Label Free Biosensing. IEEE Access (2023), 1--1. https://doi.org/10.1109/ACCESS.2023.3253563Google Scholar
- Sushil Kumar Jain, Amit Mahesh Joshi, and Arun Dev Dwivedi. 2020. Technology and modeling of DNTT organic thin-film transistors. In Advanced Technologies for Next Generation Integrated Circuits. Institution of Engineering and Technology, 197--211.Google Scholar
- Sumeet Kalra, Mamidala Jagadesh Kumar, and Anuj Dhawan. 2016. Dielectricmodulated field effect transistors for DNA detection: Impact of DNA orientation. IEEE Electron Device Lett. 37, 11 (2016), 1485--1488.Google ScholarCross Ref
- Chang-Hoon Kim, Jae-Hyuk Ahn, Kyung-Bok Lee, Cheulhee Jung, Hyun Gyu Park, and Yang-Kyu Choi. 2012. A new sensing metric to reduce data fluctuations in a nanogap-embedded field-effect transistor biosensor. IEEE Trans. Electron Devices 59, 10 (2012), 2825--2831.Google ScholarCross Ref
- Ulrike Kraft, Kazuo Takimiya, Myeong Jin Kang, Reinhold Rödel, Florian Letzkus, Joachim N Burghartz, Edwin Weber, and Hagen Klauk. 2016. Detailed analysis and contact properties of low-voltage organic thin-film transistors based on DNTT and its didecyl and diphenyl derivatives''. Org. Electron. 35 (2016), 33--40,.Google ScholarCross Ref
- B Acharya Mahalaxmi and G P Mishra. 2020--12-01. Design and Analysis of Dual-Metal-Gate Double-Cavity Charge-Plasma-TFET as a Label-Free Biosensor. IEEE Sens. J. 20, 23 (2020-12-01), 13969--13975,.Google Scholar
- T Minamiki, Y Sasaki, S Tokito, and T Minami. 2017. Label-free direct electrical detection of a histidine-rich protein with subfemtomolar sensitivity using an organic field-effect transistor. ChemistryOpen 6 (2017), 472--475.Google ScholarCross Ref
- Tsukuru Minamiki, Shizuo Tokito, and Takuya Minami. 2019. Fabrication of a Flexible Biosensor Based on an Organic Field-Effect Transistor for Lactate Detection. Analytical Sciences 35, 1 (2019), 103--106. https://doi.org/10.2116/ analsci.18SDN02Google ScholarCross Ref
- Rakhi Narang, Manoj Saxena, and Mridula Gupta. 2015. Comparative analysis of dielectric-modulated FET and TFET-based biosensor. IEEE Trans. Nanotechnol. 14, 3 (2015), 427--435.Google ScholarDigital Library
- S Rashid, F Bashir, and F A Khanday. 2021-08-15. Dielectrically Modulated Label- Free Metal Controlled Organic Thin Film Transistor for Biosensing Applications. IEEE Sens. J. 21, 16 (2021-08-15), 18318--18325,.Google ScholarCross Ref
- Deniz Sadighbayan, Aamir Minhas-Khan, and Ebrahim Ghafar-Zadeh. 2021. Laser-Induced Graphene-Functionalized Field-Effect Transistor-Based Biosensing: A Potent Candidate for COVID-19 Detection. IEEE Trans. Nanobioscience 21, 2 (2021), 232--245.Google ScholarCross Ref
- Indu Sarangadharan, Anil Kumar Pulikkathodi, Chia-Ho Chu, Yen-Wen Chen, Abiral Regmi, Pei-Chi Chen, Chen-Pin Hsu, and Yu-Lin Wang. 2018. Review-high field modulated FET biosensors for biomedical applications. ECS J. Solid State Sci. Technol. 7, 7 (2018), 3032--3042.Google ScholarCross Ref
- Susanne Scheinert, Tarek Zaki, Reinhold Rödel, Ingo Hörselmann, Hagen Klauk, and Joachim N Burghartz. 2014. Numerical analysis of capacitance compact models for organic thin-film transistors. Org. Electron. 15, 7 (Jul. 2014), 1503--1508.Google ScholarCross Ref
- G Seo, G Lee, M J Kim, S H Baek, M Choi, K B Ku, C S Lee, and S J Kim. 2020-08. Correction to Rapid Detection of COVID-19 Causative Virus (SARS-CoV-2) in Human Nasopharyngeal Swab Specimens Using FieldEffect Transistor-Based Biosensor. ACS Nano 14, 9 (2020-08), 12257--12258,.Google Scholar
- Shradhya Singh, Navaneet Kumar Singh, and Sangeeta Singh. 2023. Breast-Cancer Biomarker (C-erbB-2) Detection in Saliva/Serum Based on InGaAs/Si Heterojunction Dopingless TFET Biosensor. IEEE Transactions on NanoBioscience 22, 1 (2023), 28--37. https://doi.org/10.1109/TNB.2021.3139345Google ScholarCross Ref
- Chenfang Sun, Xue Wang, Muhammad Aminu Auwalu, Shanshan Cheng, and Wenping Hu. 2021. Organic thin film transistors-based biosensors. EcoMat eom2.12094 (2021).Google Scholar
- Nur Syahadah Yusof, Mohamed Fauzi Packeer Mohamed, Nor Azlin Ghazali, Muhammad Firdaus Akbar Jalaludin Khan, Safizan Shaari, and Mohd Nazim Mohtar. 2022. Evolution of solution-based organic thin-film transistor for healthcare monitoring-- from device to circuit integration: A review. Alex. Eng. J. 61, 12 (2022), 11405--11431.Google ScholarCross Ref
- Tarek Zaki, Susanne Scheinert, Ingo Hörselmann, Reinhold Rödel, Florian Letzkus, Harald Richter, Ute Zschieschang, Hagen Klauk, and Joachim N. Burghartz. 2014. Accurate Capacitance Modeling and Characterization of Organic Thin-Film Transistors. IEEE Transactions on Electron Devices 61, 1 (2014), 98--104.Google ScholarCross Ref
Index Terms
- OTFT Based Biosensor for Detection of Breast Cancer Biomarker (C-erbB-2)
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