Effects of CLDN9 on Proliferation of Uterine Corpus Endometrioid Carcinoma Cells
Authors: 
Jiayu Zhang, Pei Kuang, Fujian Wan, Yingjie Zhang, Wenhua Zhang, Xiaoyu ZhangAuthors Info & Claims
Jiayu Zhang, Pei Kuang, Fujian Wan, Yingjie Zhang, Wenhua Zhang, Xiaoyu ZhangAuthors Info & ClaimsPages 136 - 142
Abstract
Claudin 9 (CLDN9) is a member of the claudin family. CLDN9 is aberrantly expressed in a variety of tumors, but the biological role of CLDN9 in uterine corpus endometrioid carcinoma is unknown. In this study, CLDN9 was analyzed by various public online databases, suggesting that its expression was elevated in uterine corpus endometrioid carcinoma and confirmed by RT-qPCR and Western Blot assays in UCEC cell lines in vitro. In addition, knockdown of CLDN9 expression was shown to inhibit the proliferation of UCEC cells using cck8 and EdU assays. These results provide a theoretical basis for CLDN9 as a potential uterine corpus endometrioid carcinoma marker and a new clinical therapeutic target.
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Index Terms
- Effects of CLDN9 on Proliferation of Uterine Corpus Endometrioid Carcinoma Cells
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May 2023
313 pages
ISBN:9798400700385
DOI:10.1145/3608164
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Published: 07 November 2023
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ICBBT 2023
ICBBT 2023: 2023 15th International Conference on Bioinformatics and Biomedical Technology
May 26 - 28, 2023
Xi'an, China
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