Xiaofeng Xu
ABSTRACT
The brain consists of massive nuclei with different functions. In neuroscience research, the precise recognition and delineation of nucleus boundaries is the crux of brain atlas illustration. Here, we propose a method based on Markov Random Field. This method introduces fractional differentiation into texture feature extraction and a new potential energy function is defined based on kernel region information. To handle the problem of large data volume, we propose a strategy of dual MRF processing with down sampling for pre classification. Finally, the fuzzy entropy criterion is used to optimize the segmentation results. Experiments on model data and real tissue slice data show that this method can not only segment the regions with obvious differences in the density of the nuclei with insignificant differences in the density of nuclei, but also divide the nuclei without insignificant density differences by the cell shapes and textures. In addition, this method can not only segment a specific target kernel in one calculation, but also simultaneously partition multiple target kernels. The segmentation algorithm shows great potential for illustrating high-resolution 3D brain atlases.
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Index Terms
- Automatic Segmentation Method for the Nuclei Contour of High Resolution Rat Brain
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