Low-intensity focused ultrasound stimulation targeted on M1 ameliorates motor dysfunctions in hemi-parkinsonian rats.
Authors: 
Tianyi Sun, Chunchan Li, Rong Liang, Ling Wang, Yutao Tian, Chenguang Zheng, Jiajia Yang, Dong MingAuthors Info & Claims
Tianyi Sun, Chunchan Li, Rong Liang, Ling Wang, Yutao Tian, Chenguang Zheng, Jiajia Yang, Dong MingAuthors Info & ClaimsPages 141 - 146
Abstract
Parkinson's disease (PD) is the fastest-growing neurodegenerative disease in the world. Motor dysfunctions related to the motor cortex, are the most common clinical manifestation of PD. In previous studies, it has been proved that Low-intensity focused ultrasound stimulation (LIFUS) is an effective therapy for PD and the primary motor cortex (M1) is considered to be the central hub responsible for action planning and execution of movement. It remains unknown whether LIFUS targeted on M1 could improve motor deficit, and which motor symptoms can be improved. In addition, we evaluated the long-term effects of 14 consecutive days of LIFUS in the treatment of PD. The open field test results showed slowness of movement recovered with an increase in walking distance and a decrease in resting time. The gait test revealed that gait function (eg., freezing of gait and postural instability) has a significant improvement after LIFUS. The rotarod test suggests that the coordination ability of PD rats undergoing LIFUS was significantly better. We further found that this effect lasted for at least 7 days. Our study evaluates the therapeutic efficacy of LIFUS and provides a new target and a therapeutic strategy therapeutic strategy for further clinical application of LIFUS in PD.
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Index Terms
- Low-intensity focused ultrasound stimulation targeted on M1 ameliorates motor dysfunctions in hemi-parkinsonian rats.
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November 2023
295 pages
ISBN:9798400708343
DOI:10.1145/3637732
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Published: 28 February 2024
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- the Lingang Laboratory
- the China Post-doctoral Science Foundation
- National Natural Science Foundation of China
- National Natural Science Foundation of China
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ICBBE 2023
ICBBE 2023: 2023 10th International Conference on Biomedical and Bioinformatics Engineering
November 9 - 12, 2023
Kyoto, Japan
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