Heterogeneous Graph Guided Contrastive Learning for Spatially Resolved Transcriptomics Data
Pages 8287 - 8295
Abstract
Spatial transcriptomics provides revolutionary insights into cellular interactions and disease development mechanisms by combining high-throughput gene sequencing and spatially resolved imaging technologies to analyze genes naturally associated with spatially variable tissue genes. However, existing methods typically map aggregated multi-view features into a unified representation, ignoring the heterogeneity and view independence of genes and spatial information. To this end, we construct a heterogeneous Graph guided Contrastive Learning (stGCL) for aggregating spatial transcriptomics data. The method is guided by the inherent heterogeneity of cellular molecules by dynamically coordinating triple-level node attributes through comparative learning loss distributed across view domains, thus maintaining view independence during the aggregation process. In addition, we introduce a cross-view hierarchical feature alignment module employing a parallel approach to decouple spatial and genetic views on molecular structures while aggregating multi-view features according to information theory, thereby enhancing the integrity of inter- and intra-views. Rigorous experiments demonstrate that stGCL outperforms existing methods in various tasks and related downstream applications.
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Index Terms
- Heterogeneous Graph Guided Contrastive Learning for Spatially Resolved Transcriptomics Data
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Published In
October 2024
11719 pages
ISBN:9798400706868
DOI:10.1145/3664647
- General Chairs:
- Jianfei Cai,
- Mohan Kankanhalli,
- Balakrishnan Prabhakaran,
- Susanne Boll,
- Program Chairs:
- Ramanathan Subramanian,
- Liang Zheng,
- Vivek K. Singh,
- Pablo Cesar,
- Lexing Xie,
- Dong Xu
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Published: 28 October 2024
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